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About this item

  • Prescription-Strength Acne Fighter
  • Once-Daily Application
  • Fragrance-Free & Noncomedogenic
  • Clears & Prevents Breakouts
  • Available in Multiple Sizes

Differin Adapalene Gel 0.1% Acne Treatment

Differin  |  SKU: 00299492030-Single
$2299
FSA/HSA eligible Can be bought with an FSA/HSA card — no prescription or Letter of Medical Necessity needed. We keep this up to date, but always confirm eligibility with your health plan. Learn more

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Differin Adapalene Gel 0.1% Acne Treatment

Differin Adapalene Gel 0.1% is a topical retinoid acne treatment that was once available by prescription only. Formulated to treat and prevent breakouts at the source, it works on blackheads, whiteheads, and inflammatory acne by helping normalize skin cell turnover so pores stay clear.

Designed for once-daily use, this fragrance-free, noncomedogenic gel absorbs quickly and won't clog pores. Consistent nightly application allows the acne treatment to work continuously beneath the skin's surface, helping reduce existing blemishes while working to prevent new ones from forming.

This listing is available in multiple sizes — 0.5 oz and 1.6 oz — so you can choose the tube size that best fits your routine. Simply select your preferred size above or below before adding to cart.

Because Differin is a retinoid, most users start with a pea-sized amount applied to clean, dry skin each evening, gradually building tolerance. Pair with a gentle moisturizer and daily sunscreen for best results.

How often should I apply Differin Gel?
Differin is designed for once-daily application, applied in a thin layer to clean, dry skin.
Is Differin Gel fragrance-free?
Yes, Differin Adapalene Gel 0.1% is fragrance-free and noncomedogenic, so it won't clog pores.
What sizes does Differin Gel come in?
This listing is available in 0.5 oz and 1.6 oz tubes—simply select your preferred size on the product page.
Was Differin previously a prescription-only product?
Yes, Differin's 0.1% adapalene formula was once available only by prescription and is now offered over the counter.
What type of acne does Differin treat?
Differin is formulated to help treat and prevent blackheads, whiteheads, and other common forms of acne.

Product Details

FSA/HSA Eligible Yes
Active Ingredient Adapalene 0.1%
Form Gel
Scent Fragrance-Free
Type Topical Retinoid Acne Treatment
Application Apply once daily to clean, dry skin
Comedogenic Rating Noncomedogenic
Sizes 0.5 oz; 1.6 oz
Brand Differin
SKU 00299492030

Key Features

  • Prescription-Strength Power, No Rx Needed: Delivers 0.1% adapalene, a topical retinoid once available only by prescription.
  • Simple Daily Routine: One application per day works continuously to treat and help prevent acne.
  • Gentle on Skin: Fragrance-free, noncomedogenic formula won't clog pores or irritate sensitive skin.
  • Targets Breakouts at the Source: Helps clear blackheads, whiteheads, and inflammatory acne over time.
  • Flexible Sizing: Offered in multiple tube sizes so you can pick the amount that matches your skincare routine.

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