• Free 1-3 day shipping over $49

  • 5% cash back rewards

  • Hassle-free returns

  • Trustpilot
1 10

About this item

  • Maximum Overnight Protection for Men
  • Up to 12 Hours of Heavy Absorbency
  • Confidence Core™ for Fast Moisture & Odor Control
  • Discreet, Comfortable, Underwear-Like Fit
  • Soft, Breathable Fabric Prevents Irritation

Depend Night Defense Underwear for Men

Depend  |  SKU: 55157-Pack
$24.99
$1.79/ea
FSA/HSA eligible Can be bought with an FSA/HSA card — no prescription or Letter of Medical Necessity needed. We keep this up to date, but always confirm eligibility with your health plan. Learn more

Free 1-3 day delivery over $49

Free Shipping On all orders $49+
90-Day Returns Return or exchange within 90 days
5% Cash Back Rewards on every order

You're Safe Shopping With Us

Depend Night Defense Underwear for Men

Absorbency Level
4 drops - Heavy Absorbency
Heavy

 

Regain your confidence and achieve a restful night's sleep with Depend Night Defense Underwear for Men. Specifically engineered for overnight use, these pull-up briefs provide heavy-duty protection against bladder leaks, allowing you to sleep soundly without the worry of breakthrough moisture. Designed with the male anatomy in mind, the absorbent core is strategically positioned to capture fluid where it is needed most, ensuring maximum efficacy for side, back, and stomach sleepers alike.

The secret to the superior performance of these overnight briefs is the DryShield™ technology. This advanced system quickly wicks moisture away from the skin, locking it deep within the core to prevent irritation and maintain skin health. Unlike standard daytime incontinence products, Night Defense offers reinforced side shields and a higher absorbency capacity to manage larger volumes of liquid over several hours. The fabric-like material is soft against the skin and stays quiet as you move, providing a discreet experience that feels like real underwear.

Beyond protection, these briefs prioritize comfort and dignity. The form-fitting elastic strands ensure a snug, secure fit that moves with your body, reducing the risk of gaps or bunching. Whether you are managing chronic incontinence or recovering from a medical procedure, Depend Night Defense provides the reliable, heavy-absorbency solution required to wake up feeling dry, refreshed, and ready for the day.

How is Depend Night Defense different from regular Depend Fit-Flex?
Night Defense is specifically formulated for extended wear and higher volume. It features a more robust absorbent core and enhanced leak guards designed to handle the pressure and positioning of a person lying down.
Can I wear these during the day if I have heavy leakage?
Yes. While they are optimized for overnight use, many men choose Night Defense for daytime activities or long travel where frequent changes may not be possible.
Are these briefs noticeable under pajamas?
No. Depend Night Defense is designed with a low-profile, non-bulky silhouette that fits discreetly under sleepwear or standard clothing without looking like a traditional adult diaper.
How do these help control odors?
These briefs utilize a specialized odor-neutralizing core that traps and breaks down the molecules that cause ammonia smells, keeping your bedroom environment fresh.
Is the material breathable for sensitive skin?
Absolutely. The outer cover is made from a cloth-like, breathable material that promotes airflow, helping to keep the skin cool and reduce the risk of heat-related irritation.

Product Details

FSA/HSA Eligible Yes
Backing Type Cloth-Like
Absorbency Level Heavy
Gender Male
Style Pull-Up
Brand Depend
SKU Depend Night Defense Men's
UPC n/a

Key Features

  • DryShield™ Absorption: Advanced core technology captures moisture instantly for maximum overnight dryness.
  • Male-Specific Design: Targeted protection zones shaped specifically for the male body to prevent leaks.
  • Odorguard™ Protection: Effectively neutralizes and locks in odors to ensure total discretion.
  • Soft, Quiet Fabric: Breathable, cloth-like material that feels like real underwear and stays silent during movement.
  • Secure Fit Strands: Flexible elastics provide a close-to-body fit that stays in place even if you toss and turn.

Size Chart 

Size Small / Medium Large X-Large
Style Pull Up Pull Up Pull Up
Waist 26" to 34" 35" to 43" 44" to 54"
Absorbency Heavy Heavy Heavy
Backing Cloth-Like Cloth-Like Cloth-Like
Pack Qty 16 14 12
Case Qty 64 (4 packs) 56 (4 packs) 48 (4 packs)
Color Grey Grey Grey
SKU 55156 55157 55158

Have a question about this product?

Size Chart 

Size Small / Medium Large X-Large
Style Pull Up Pull Up Pull Up
Waist 26" to 34" 35" to 43" 44" to 54"
Absorbency Heavy Heavy Heavy
Backing Cloth-Like Cloth-Like Cloth-Like
Pack Qty 16 14 12
Case Qty 64 (4 packs) 56 (4 packs) 48 (4 packs)
Color Grey Grey Grey
SKU 55156 55157 55158

Customer Reviews